2025-09-25 Release Note
The update for HyperLab on September 25, 2025, has been completed.
HyperLab Version : 2025.09.25
📣 Changelogs
1. Addition of Hyper ADME/T Properties (LogD at pH 7.4, CNS MPO)
New properties are now available through Hyper ADME/T calculations.
These newly added properties can be viewed in both the Bench and the molecule detail information pages.
LogD at pH 7.4 (LogD₇․₄)
Predicted log value of the octanol–water distribution coefficient at physiological pH 7.4, including both ionized and unionized species (dimensionless, pH-dependent).
CNS MPO
A multiparameter score (0–6) for CNS drug design; higher scores indicate greater favorability for CNS drug design. In HyperLab, the score is calculated according to the CNS MPO scoring system published in 2017, based on five physicochemical properties: LogP, TPSA, Molecular weight, Most basic pKa, and Number of hydrogen bond donors (with double weighting).
2. Improved File Upload Usability
The file upload feature has been redesigned for greater clarity and ease of use. This update introduces upload type selection, simplified merge criteria, and an upload preview, enhancing both user convenience and data management efficiency.
Key Updates
(1) Upload Type Selection When uploading a file, users must now first choose an upload method:
Add new molecules: Add all data in the file as new molecules.
Merge with existing data: Merge file data with existing Bench data to update records.
This ensures users can clearly select the method that fits their upload purpose.
(2) Simplified Merge Criteria When merging with existing data, users can now choose either molecule name or molecule structure as the merge key.
Previously, both keys had to match for a merge to proceed. Now, a single key is sufficient, simplifying the process and enabling more flexible data management.
(3) Upload Preview Before completing an upload, users can review a detailed preview of the results, including:
Total molecules in the file
Molecules to be added
Molecules to be merged
Molecules that cannot be added
If any molecules cannot be added, the system will provide a failure notice after the upload, along with the option to download a list of the failed molecules.
3. AI Assistant - Bench Selection Feature Added
Within a project, you can launch the AI Assistant and use the Select Bench option in the chat window to choose a Bench.
When asking questions with a Bench selected, the AI Assistant will reference the data from the selected Bench to provide answers.
*Bench selection is not available when the AI Assistant is in full-screen mode.
🛠️ Bug fix
Bug fixes and stability improvements have been made.
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