2026-02-24 Relese Note
The update for HyperLab on Febraury 24, 2026, has been completed.
HyperLab Version : 2026.02.24
1. Official Launch of the Covalent Research Workflow
The Covalent feature is now officially available, enabling end-to-end Covalent drug research within a single platform in HyperLab.
Covalent research can be conducted through the following workflow:
Register a Covalent-type protein
Perform Covalent library-based screening
Predict Covalent binding for individual molecules
Analyze structures in the 3D Viewer
Launch Hyper Design based on Covalent results
Depending on research objectives, each step can be used independently.
2. Addition of Covalent Protein Types
COV-type proteins have been added to support Covalent research.
※ Target residue selection is mandatory when registering a Covalent-type protein.
COV 3D Structure
Import 3D structures using PDB ID or UniProt ID
Perform Covalent docking based on experimentally determined structures
Generate structures from amino acid sequences
Support structure prediction using co-folding
3. Addition of Covalent Screening
A dedicated library-based screening feature designed for Covalent reactions has been added.
Automatic filtering of libraries based on the selected target residue
Execute screening after selecting one or more libraries
Warhead information is provided as a table field
Accessible via:
Bench → Fields → Covalent → [Protein] – Warhead field
4. Addition of Covalent Binding
Covalent binding prediction for individual molecules is now supported.
Easy reaction setup by specifying the Warhead region and selecting a Product form
Automatic recording of selected Warhead (viewable in the table field)
Custom Product form creation for flexible research workflows
5. Covalent Structure Support in 3D Viewer
Covalent Binding and Screening results can be visualized in the 3D Viewer.
View covalent bond structures
Compare Reactant and Product forms
6. Hyper Design Integration with Covalent Results
Hyper Design can be launched directly from Covalent Binding results.
Perform design while preserving the Warhead and binding region
Explore structures to improve activity and physicochemical properties
Bug fixes and stability improvements have been made.
