HyperLab Main Feature Update History

This information pertains to updates in HyperLab that may have affected users’ calculation results.

1. Hyper Binding

Update Date	HyperLab Version	Changelog	Description
March 28, 2024	2024.03.28	ES update	Exhaustive Search, our brand-new development of a binding-pose search method, and PIGNet2, our published AI for predicting protein-ligand interactions [Digital Discovery 3: 287 (2024)]. Exhaustive Search significantly increases both Hyper Binding's accuracy and speed.
October 18, 2024	2024.10.18	Improved Hyper Binding success rate	The calculation success rate of Hyper Binding has been enhanced.
November 15, 2024	2024.11.15	Improved ligand ionization handling	Corrected the ionized forms of some functional groups of ligands.
April 10, 2025	2025.04.10	Update with applied Box size calculation method	For proteins registered as 3D Structure type, the box size you set is now more precisely reflected in calculations.

2. Hyper ADME/T

Update Date	HyperLab Version	Changelog	Description
October 18, 2024	2024.10.18	Changes to the Metabolic stability	The Metabolic stability in Hyper ADME/T is now changed to Metabolic stability (H/M).
September 25, 2025	2025.09.25	New Properties Added	The items LogD at pH 7.4 and CNS MPO have been newly added.

3. Hyper Design

Update Date	HyperLab Version	Changelog	Description
August 30, 2024	2024.08.30	Changing the physicochemical property values of some molecules	The physicochemical property values of ionizable molecules added by hyperdesign have been changed.
October 18, 2024	2024.10.18	Added R group definition feature	In Hyper Design, you can now define the fragment design to a specific R-group. (Examples of R-groups: Aliphatic chains, Aryl, Heteroaryl, etc.)
November 15, 2024	2024.11.15	Performance improvement	The multiple selection bug in the fragment library has been fixed. The Hyder Design algorithm has been improved to allow ‘Add’ feature to bond with carbons that have double bonds.
August 28, 2025	2025.08.28	User Interface improvement	When selecting Replace, the selected area and the selectable areas are now clearly distinguished.
October 30, 2025	2025.10.30	Hyper Design execution method improved	The structure has been updated to allow Hyper Design to be executed separately for each protein.

4. Hyper Screening

Update Date	HyperLab Version	Changelog	Description
August 9, 2024	2024.08.09	PAINS Filter applied	The PAINS (Pan-Assay Interference Compounds) filter has been applied to the HyperLab library.

5. 3D Viewer

Update Date	HyperLab Version	Changelog	Description
November 15, 2024	2024.11.15	Interaction improvement	Enhanced to analyze interaction information with DNA/RNA receptors.

6. Hyper Binding Co-folding

Update Date	HyperLab Version	Changelog	Description
April 10, 2025	2025.04.10	New Feature Added	The Hyper Binding Co-folding feature has been newly added.
October 30, 2025	2025.10.30	Performance improvement	Updated the list of supported PTM cases.

7. Hyper Screening X

Update Date	HyperLab Version	Changelog	Description
April 10, 2025	2025.04.10	New Feature Added	The Hyper Screening X feature has been newly added.
August 11, 2025	2025.08.11	Model Performance Improvement	The model performance of Hyper Screening X has been improved.
November 13, 2025	2025.11.13	Model Performance Improvement	Improved structural diversity in generated molecules after training. As of October 2025, unavailable building blocks have been excluded from training and generation results.

8. Analysis

Update Date	HyperLab Version	Changelog	Description
August 28, 2025	2025.08.28	New Feature Added	The SAR Analysis feature has been newly added.