HyperLab Main Feature Update History
This information pertains to updates in HyperLab that may have affected users’ calculation results.
1. Hyper Binding
March 28, 2024
2024.03.28
ES update
Exhaustive Search, our brand-new development of a binding-pose search method, and
PIGNet2, our published AI for predicting protein-ligand interactions [Digital Discovery 3: 287 (2024)].
Exhaustive Search significantly increases both Hyper Binding's accuracy and speed.
October 18, 2024
2024.10.18
Improved Hyper Binding success rate
The calculation success rate of Hyper Binding has been enhanced.
November 15, 2024
2024.11.15
Improved ligand ionization handling
Corrected the ionized forms of some functional groups of ligands.
April 10, 2025
2025.04.10
Update with applied Box size calculation method
For proteins registered as 3D Structure type, the box size you set is now more precisely reflected in calculations.
2. Hyper ADME/T
October 18, 2024
2024.10.18
Changes to the Metabolic stability
The Metabolic stability in Hyper ADME/T is now changed to Metabolic stability (H/M).
3. Hyper Design
August 30, 2024
2024.08.30
Changing the physicochemical property values of some molecules
The physicochemical property values of ionizable molecules added by hyperdesign have been changed.
October 18, 2024
2024.10.18
Added R group definition feature
In Hyper Design, you can now define the fragment design to a specific R-group. (Examples of R-groups: Aliphatic chains, Aryl, Heteroaryl, etc.)
November 15, 2024
2024.11.15
Performance improvement
The multiple selection bug in the fragment library has been fixed.
The Hyder Design algorithm has been improved to allow ‘Add’ feature to bond with carbons that have double bonds.
4. Hyper Screening
August 9, 2024
2024.08.09
PAINS Filter applied
The PAINS (Pan-Assay Interference Compounds) filter has been applied to the HyperLab library.
5. 3D Viewer
November 15, 2024
2024.11.15
Interaction improvement
Enhanced to analyze interaction information with DNA/RNA receptors.
6. Hyper Binding Co-folding
April 10, 2025
2025.04.10
New Feature Added
The Hyper Binding Co-folding feature has been newly added.
7. Hyper Screening X
April 10, 2025
2025.04.10
New Feature Added
The Hyper Screening X feature has been newly added.
Last updated